Every GLP-1, compared
Average weight-loss figures are trial averages over roughly 16–18 months; individual results vary widely. Diabetes brands are used off-label for weight loss.
| Drug | Molecule | Form | Approved for | Avg weight loss | Maker |
|---|---|---|---|---|---|
| Wegovy | Semaglutide (GLP-1) | Weekly injection | Weight management; CV risk | ~15% | Novo Nordisk |
| Zepbound | Tirzepatide (GIP/GLP-1) | Weekly injection | Weight management; sleep apnea | ~20% | Eli Lilly |
| Ozempic | Semaglutide (GLP-1) | Weekly injection | Type 2 diabetes; CV risk | (off-label) | Novo Nordisk |
| Mounjaro | Tirzepatide (GIP/GLP-1) | Weekly injection | Type 2 diabetes | (off-label) | Eli Lilly |
| Saxenda | Liraglutide (GLP-1) | Daily injection | Weight management | ~5–8% | Novo Nordisk |
| Rybelsus | Semaglutide (GLP-1) | Daily pill | Type 2 diabetes | (off-label) | Novo Nordisk |
See the full GLP-1 medications guide and receptor agonist list for how ingredients and brands relate. Figures are general and change, so always confirm against current FDA labeling.
Direct comparisons
The match-ups people search most, answered with a table and a clear "which is right for you."
Ozempic vs Wegovy
Same drug, different job, dose, approval, weight loss and cost.
Compare → Weight lossZepbound vs Wegovy
Tirzepatide vs semaglutide, which wins on average weight loss.
Compare → DiabetesMounjaro vs Ozempic
The dual-agonist vs the classic GLP-1, head to head.
Compare → MoleculeSemaglutide vs Tirzepatide
Single vs dual agonist, and the brands each is sold under.
Compare → Weight lossBest GLP-1 for weight loss
An honest ranking, and why "best" isn't just the biggest number.
Read → Big pictureGLP-1s vs bariatric surgery
Medication or surgery? Results, durability, cost and who each suits.
Read →Frequently asked questions
Which GLP-1 is best for weight loss?
Some weight-management trials report higher average results with tirzepatide than with semaglutide or liraglutide, but these are study averages rather than a universal ranking or personal forecast. Tolerability, approved use, cost, coverage, availability and health history all matter. A qualified clinician makes the treatment decision.
What's the difference between Ozempic and Wegovy?
Both contain semaglutide, but they have different FDA-approved uses and product labeling. Ozempic is indicated for type 2 diabetes and related cardiovascular or kidney risk reductions in specified adults. Wegovy is indicated for chronic weight management and certain cardiovascular risk reduction. Check the current FDA-approved labeling for details.
Are Mounjaro and Zepbound the same drug?
Both contain tirzepatide, but they have different FDA-approved uses and product labeling. Mounjaro is indicated for type 2 diabetes, while Zepbound is indicated for chronic weight management and certain adults with moderate-to-severe obstructive sleep apnea and obesity. A clinician can explain which approved use applies to you.